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Ketamine Hydrochloride (HCL) is a chemical compound used primarily for its anesthetic and dissociative properties. It has specific chemical characteristics that define its structure, stability, and interaction within biological systems. Here are the key chemical specifications of Ketamine HCL:
1. Chemical Name and Formula
- IUPAC Name: 2-(2-chlorophenyl)-2-(methylamino)cyclohexanone hydrochloride
- Molecular Formula: C₁₃H₁₆ClNO · HCl
- Molar Mass: 274.2 g/mol (for Ketamine base), 290.2 g/mol (for Ketamine HCL salt)
2. Physical Properties : Buy Ketamine HCL Online
- Appearance: White crystalline powder or colorless crystals
- Melting Point: 262-265°C
- Solubility: Soluble in water, methanol, and ethanol
- Stability: Stable under normal conditions but may decompose on exposure to light. Solutions are best stored in tightly sealed, dark containers.
3. Chemical Structure and Characteristics
- Structural Formula: Buy Ketamine HCL Online has a cyclohexanone backbone with two substituent groups: a chlorine-substituted phenyl group and a methylamine group attached to the nitrogen.
- Stereochemistry: Exists in two enantiomeric forms (S)-(+)-ketamine and (R)-(-)-ketamine, with (S)-ketamine generally being the more pharmacologically active isomer.
4. Pharmacological Properties
- Mechanism of Action: Primarily acts as an NMDA receptor antagonist, which inhibits excitatory neurotransmission in the central nervous system. It may also interact with other receptors, including opioid, dopamine, and serotonin receptors.
- Half-life: Approximately 2-3 hours in humans, although it can vary based on metabolic factors.
- Metabolism: Metabolized in the liver, primarily by cytochrome P450 enzymes, into norketamine and dehydronorketamine.
5. Purity and Impurities : Buy Ketamine HCL Online
- Purity: Pharmaceutical-grade ketamine HCL typically has a purity level of >99%.
- Impurities: Trace impurities may include unreacted reagents, by-products from synthesis, and residual solvents. Pharmaceutical guidelines dictate strict limits on allowable impurities to ensure patient safety.
6. Common Forms and Dosages of Buy Ketamine HCL Online
- Forms: Available in various forms, including injectable liquid (IV, IM solutions), nasal sprays, and as a crystalline powder.
- Common Doses: Medically, ketamine is dosed based on the patient’s weight and the intended application. For anesthesia, a typical IV dose might be 1-2 mg/kg, while sub-anesthetic doses for depression treatment are often in the range of 0.5 mg/kg.
7. Storage and Handling of Buy Ketamine HCL Online
- Storage Conditions: Should be stored at room temperature in a dry, dark location. It is sensitive to light, so solutions are usually stored in amber-colored vials.
- Handling Precautions: Avoid inhalation and contact with skin and eyes. Protective gear, such as gloves and masks, should be worn when handling.
8. Safety and Toxicology of Buy Ketamine HCL Online
- LD50 (Lethal Dose): The LD50 for ketamine HCL varies by administration route but is approximately 350 mg/kg in rats (IV). For humans, doses over 10 mg/kg can lead to severe effects.
- Side Effects: At therapeutic doses, ketamine can cause dissociation, dizziness, nausea, and hallucinations. Chronic use may lead to bladder toxicity (ketamine cystitis) and cognitive impairments.
Ketamine HCL’s properties are finely tuned for clinical use but also call for careful handling due to its powerful effects and potential for misuse.
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